The putative E5 open reading frame of cottontail rabbit papillomavirus is dispensable for papilloma formation in domestic rabbits.

@article{Brandsma1992ThePE,
  title={The putative E5 open reading frame of cottontail rabbit papillomavirus is dispensable for papilloma formation in domestic rabbits.},
  author={Janet L. Brandsma and Zhi Hong Yang and Daniel DiMaio and Stephen W. Barthold and Eric Arthur Johnson and Weidong Xiao},
  journal={Journal of virology},
  year={1992},
  volume={66 10},
  pages={6204-7}
}
In the cottontail rabbit papillomavirus (CRPV)-rabbit system, recombinant CRPV DNA can induce papillomas. This investigation was undertaken to evaluate whether the E5 open reading frame (ORF) of CRPV is required for papilloma formation. The CRPV genome we utilized, CRPV-WA, was sequenced in the E5 region and was found to contain one deletion, two insertions, and one transition mutation compared with CRPV-KS, the CRPV genome that has been fully sequenced. Despite these differences, an intact E5… CONTINUE READING

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