The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein.

@article{Overmeyer1998TheP,
  title={The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein.},
  author={J. H. Overmeyer and Angela L Wilson and Robert A Erdman and William A Maltese},
  journal={Molecular biology of the cell},
  year={1998},
  volume={9 1},
  pages={223-35}
}
Posttranslational modification of Rab proteins by geranylgeranyltransferase type II requires that they first bind to Rab escort protein (REP). Following prenylation, REP is postulated to accompany the modified GTPase to its specific target membrane. REP binds preferentially to Rab proteins that are in the GDP state, but the specific structural domains involved in this interaction have not been defined. In p21 Ras, the alpha2 helix of the Switch 2 domain undergoes a major conformational change… CONTINUE READING
11 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Similar Papers

Loading similar papers…