The purine nucleoside adenosine in retinal ischemia-reperfusion injury

  title={The purine nucleoside adenosine in retinal ischemia-reperfusion injury},
  author={Greg J. Ghiardi and Jeffrey M. Gidday and Steven Roth},
  journal={Vision Research},
Adenosine, an intercellular messenger that is a product of the metabolism of ATP, plays a major role in neuronal and vascular responses of the retina to alterations in oxygen delivery. Significant changes in adenosine concentration have been measured in the retina during both ischemia and during the subsequent reperfusion period which result in important, but complex, functional effects. Adenosine A1 receptor stimulation produces a protective effect during ischemia, whereas overstimulation of… CONTINUE READING
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Purine nucleoside concentration during reperfusion following retinal ischemia in rats

  • S. Roth, S. S. Park, C. Sikorski, J. Osinski, R. Chan
  • Current Eye Research,
  • 1997
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