The purification and characterization of fetal liver hematopoietic stem cells.

  title={The purification and characterization of fetal liver hematopoietic stem cells.},
  author={Sean J Morrison and Houman D Hemmati and Antoni M. Wandycz and Irving L Weissman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 22},
Thy-1loSca-1+Lin-Mac-1+CD4- cells have been isolated from the livers of C57BL-Thy-1.1 fetuses. This population appears to be an essentially pure population of hematopoietic stem cells (HSC), in that injection of only six cells into lethally irradiated adult recipients yields a limit dilution frequency of donor cell-reconstituted mice. Sixty-seven to 77% of clones in this population exhibit long-term multilineage progenitor activity. This population appears to include all long-term multilineage… CONTINUE READING
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