The pupil light reflex in Leber's hereditary optic neuropathy: evidence for preservation of melanopsin-expressing retinal ganglion cells.

@article{Moura2013ThePL,
  title={The pupil light reflex in Leber's hereditary optic neuropathy: evidence for preservation of melanopsin-expressing retinal ganglion cells.},
  author={A. L. Moura and B. Nagy and C. La Morgia and P. Barboni and A. F. Oliveira and S. Salom{\~a}o and A. Berezovsky and Milton Nunes de Moraes-Filho and C. F. Chicani and R. Belfort and V. Carelli and A. Sadun and D. Hood and D. Ventura},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 7},
  pages={
          4471-7
        }
}
PURPOSE To investigate the pupillary light reflex (PLR) of patients with severe loss of vision due to Leber's Hereditary Optic Neuropathy (LHON) in the context of a proposed preservation of melanopsin-expressing retinal ganglion cells (mRGCs). METHODS Ten LHON patients (7 males; 51.6 ± 14.1 years), with visual acuities ranging from 20/400 to hand motion perception and severe visual field losses, were tested and compared with 16 healthy subjects (7 males; 42.15 ± 15.4 years) tested as controls… Expand
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