The pulmonary blood-gas barrier in the avian embryo: inauguration, development and refinement.

@article{Makanya2011ThePB,
  title={The pulmonary blood-gas barrier in the avian embryo: inauguration, development and refinement.},
  author={Andrew Ndegwa Makanya and Ruslan Hlushchuk and Valentin Djonov},
  journal={Respiratory physiology & neurobiology},
  year={2011},
  volume={178 1},
  pages={30-8}
}
In vertebrates, efficient gas exchange depends primarily on establishment of a thin blood-gas barrier (BGB). The primordial air conduits of the developing avian lung are lined with a cuboidal epithelium that is ultimately converted to a squamous one that participates in the formation of the BGB. In the early stages, cells form intraluminal protrusions (aposomes) then transcellular double membranes separating the aposome from the basal part of the cell establish, unzip and sever the aposome from… CONTINUE READING