The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.

@article{Martino2014ThePL,
  title={The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.},
  author={Thiago Martino and Fernanda C J Magalh{\~a}es and Graça A. Justo and Marsen Garcia Pinto Coelho and Chaquip Daher Netto and Paulo Roberto Costa and K{\'a}tia C Carvalho Sabino},
  journal={Bioorganic & medicinal chemistry},
  year={2014},
  volume={22 12},
  pages={3115-22}
}
The incidence of cancer grows annually worldwide and in Brazil it is the second cause of death. The search for anti-cancer drugs has then become urgent. It depends on the studies of natural and chemical synthesis products. The antitumor action of LQB-118, a pterocarpanquinone structurally related to lapachol, has been demonstrated to induce mechanisms linked to leukemia cell apoptosis. This work investigated some mechanisms of the in vitro antitumor action of LQB-118 on prostate cancer cells… CONTINUE READING

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