The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease

  title={The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease},
  author={Andrea Zangara},
  journal={Pharmacology Biochemistry and Behavior},
  • A. Zangara
  • Published 1 June 2003
  • Biology, Medicine
  • Pharmacology Biochemistry and Behavior

Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?

The most recent discovery that H upA may reduce brain iron accumulation lends further support to the argument that HupA could serve as a potential disease-modifying agent for AD and also other neurodegenerative disorders by significantly slowing down the course of neuronal death.

Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology

Several HupA-related features are addressed in this review, including not only its therapeutic properties, but also its chemistry, biological and chemical sources, structure–activity relationship, pharmacokinetics and toxicology, which are discussed in detail covering the literature published from 1962 to 2014.

Huperzinea: Pharmacological and Therapeutic Potential

The present review highlights the pharmacological potential of Huperzine with its pharmacokinetics and pharmacokinetic studies and it’s rational for future prospective.

Role of Huperzine a in the Treatment of Alzheimer's Disease

Although use of huperzine A has shown promising results in patients with AD, data supporting its use are limited by weak study design, and largescale, randomized, placebo-controlled trials are necessary to establish the role of hUPZine A in the treatment of AD.

Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations

The present review covers the pathophysiology of HD, available biomarkers, phytomedicines explored against HD, ongoing clinical trials on herbal drugs exclusively for treating HD and their nanocarriers, along with their potential neuroprotective effects.

Huperzin A: Gölgede Kalmış Bir Nootropik Ajan

According to the obtained findings, Huperzine A has multiple action mechanisms due to its acetylcholinesterase inhibitory, neuroprotective and neurogenesissupporting activities, and has significant nootropic activity against cognitive impairments induced by various experimental models.


Cucumber cerebrosides possess neuroprotective effects against A protein, which may be a potential nutritional preventive strategy for neurodegenerative diseases with little or no side effects.

Neuroprotective effects of Huperzine-A in aluminum induced neurotoxicity in hippocampus of mice

Huperzine A (HupA), derived from the Chinese herb Huperzia serrata, is an inhibitor of acetylcholinesterase (AChE) and its use in aluminum induced neurotoxicity has not been reported, and Quantitative study found that 0.2mg/Kg of synthetic HuperZine A given intraperitoneally, was able to increase neuronal count signi icantly.



Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease.

A comprehensive survey of the progress in chemical and pharmacological studies of H upA including the isolation and structure elucidation, pharmacological actions, total synthesis, SAR studies and the future development of HupA is dealt with.

[Drug evaluation of huperzine A in the treatment of senile memory disorders].

The result showed that the curative effect of huperzine A was significant and only a few patients felt slight dizziness and this did not affect the therapeutic effects.

Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy.

Based on laboratory and x-ray crystallography studies, HupA does appear to be a potent inhibitor of acetylcholinesterase (AChE) and has a number of other pharmacological properties of clinical interest.

[Huperzine a: an acetylcholinesterase inhibitor with high pharmacological potential].

Huperzine A is an alkaloid isolated from a chinese club-moss which possesses a high pharmacological potential and is under clinical evaluation for the palliative treatment of Alzheimer's disease and the pretreatment of poisoning by organophosphorous nerve agents.

Therapeutic effects of huperzine A on the aged with memory impairment

The therapeutic value of huperzine A 30 μg is even superior than hydergine 600 μg, and the memory improved l-4h after the injection and sustained for 8h or so.

[Pharmacokinetics of huperzine A in rats and mice].

Huperzine A, a new alkaloid first isolated in China from Huperzia serratacl), is a reversible cholinesterase inhibitor). Clinical studies have shown that huperzine A can improve muscle weakness of

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.

  • S. XuZ. Gao X. Chai
  • Medicine, Psychology
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1995
Hup is a promising drug for symptomatic treatment of Alzheimer's disease and was better than placebo in patients treated with Hup, with improvements in memory, cognitive, and behavioral functions.

Natural and Synthetic Huperzine A: Effect on Cholinergic Function in Vitro and in Vivo a

The results indicate that the racemic mixture of (±) Huperzine A has a weaker biological activity than the natural product (−)HuperZine A, presumably due to the presence in the mixture of (+)Hu perzine B, which is considerably less potent than the (−)isomer.