The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease

@article{Zangara2003ThePO,
  title={The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease},
  author={Andrea Zangara},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={75},
  pages={675-686}
}
  • A. Zangara
  • Published 1 June 2003
  • Biology, Medicine
  • Pharmacology Biochemistry and Behavior

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References

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Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease.

A comprehensive survey of the progress in chemical and pharmacological studies of H upA including the isolation and structure elucidation, pharmacological actions, total synthesis, SAR studies and the future development of HupA is dealt with.

Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy.

Based on laboratory and x-ray crystallography studies, HupA does appear to be a potent inhibitor of acetylcholinesterase (AChE) and has a number of other pharmacological properties of clinical interest.

[Huperzine a: an acetylcholinesterase inhibitor with high pharmacological potential].

Huperzine A is an alkaloid isolated from a chinese club-moss which possesses a high pharmacological potential and is under clinical evaluation for the palliative treatment of Alzheimer's disease and the pretreatment of poisoning by organophosphorous nerve agents.

Therapeutic effects of huperzine A on the aged with memory impairment

The therapeutic value of huperzine A 30 μg is even superior than hydergine 600 μg, and the memory improved l-4h after the injection and sustained for 8h or so.

[Pharmacokinetics of huperzine A in rats and mice].

Huperzine A, a new alkaloid first isolated in China from Huperzia serratacl), is a reversible cholinesterase inhibitor). Clinical studies have shown that huperzine A can improve muscle weakness of

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.

  • S. XuZ. Gao X. Chai
  • Medicine, Psychology
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1995
Hup is a promising drug for symptomatic treatment of Alzheimer's disease and was better than placebo in patients treated with Hup, with improvements in memory, cognitive, and behavioral functions.

Natural and Synthetic Huperzine A: Effect on Cholinergic Function in Vitro and in Vivo a

The results indicate that the racemic mixture of (±) Huperzine A has a weaker biological activity than the natural product (−)HuperZine A, presumably due to the presence in the mixture of (+)Hu perzine B, which is considerably less potent than the (−)isomer.

Huperzine-A in capsules and tablets for treating patients with Alzheimer disease.

  • S. XuZ. Cai B. Feng
  • Medicine, Biology
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1999
There is equal efficacy and safety between Hup in capsule and tablet for treating patients with AD, and Hup can reduce the pathological changes of the oxygen free radicals in the plasma and erythrocytes of patients withAD.
...