The psychobiology of obsessive-compulsive disorder: How important is the role of disgust?

  title={The psychobiology of obsessive-compulsive disorder: How important is the role of disgust?},
  author={Dan J. Stein and Yijun Liu and Nathan Andrew Shapira and Wayne K. Goodman},
  journal={Current Psychiatry Reports},
Psychobiologic models of obsessive-compulsive disorder (OCD) have focused on cortico-striatal-thalamic-cortical (CTSC) circuits, noting normal function in cognitive and motoric procedural strategies. Such models have relied on the classification of OCD as an anxiety disorder, seldom exploring other relevant emotions. Based on the hypothesis that a central emotion in OCD is disgust, the authors review the literature on its psychobiology and its relevance to current models of OCD. There are… 

The neurocircuitry of obsessive–compulsive disorder and disgust

Disgust in Anxiety and Obsessive-Compulsive Disorders: Recent Findings and Future Directions

Recent evidence implicating disgust in anxiety and OCD is examined, highlighting recent measurement and methodological improvements and an increased focus on disgust-related mechanisms that contribute to psychopathology, such as disgust-based learning and emotion regulation.

Obsessive-compulsive spectrum disorders: a multidimensional approach.

Psychobiology of Anxiety Disorders and Obsessive-Compulsive Spectrum Disorders

Clinicians must also recognize that individual anxiety and obsessive-compulsive spectrum conditions, including disorders characterized by body-focused repetitive behaviors, have distinct psychobiological underpinnings and require different treatment approaches.

Neurocircuitry of disgust and anxiety in obsessive-compulsive disorder: A positron emission tomography study

O OCD may be characterized by a disruption in disgust processing, such that there is a decrease in appropriate disgust and an increase in inappropriate disgust (such as that evoked by contamination stimuli).

OCD: obsessive–compulsive … disgust? The role of disgust in obsessive–compulsive disorder

How elevated behavioural and biological markers of disgust reported in OCD populations support the need for alternative clinical treatment strategies and theoretical models of OCD are discussed.

Windows on the brain : functional neuroimaging studies in obsessive-compulsive disorder

It is demonstrated that that spatial working memory deficits in OCD and their functional anatomical correlates are, at least to some extent, related to OCD symptomatology, i.e. state dependent.



Disgust implicated in obsessive–compulsive disorder

Impaired recognition of disgust is consistent with the neurology of OCD and with the idea that abnormal experience of disgust may be involved in the genesis of obsessions and compulsions.

The cognitive-affective neuroscience of obsessive-compulsive disorder

There is substantial evidence that obsessive-compulsive disorder (OCD) is mediated by specific cortico-striatalthalamic-cortical circuits and this model is becoming integrated with a range of data including brain imaging, genetic, immunologic, and neurochemical findings.

Symptoms of obsessive-compulsive disorder.

The four symptom dimensions identified in this study are largely congruent with those identified in earlier reports, and may be of value in future genetic, neurobiological, and treatment response studies.

Emotional responsiveness and obsessive-compulsive behaviour

Abstract Several clinicians have proposed that patients with obsessive-compulsive disorder (OCD) are unusually sensitive to unpleasant events. We tested a non-clinical sample of obsessive-compulsive

A differential neural response in obsessive–compulsive disorder patients with washing compared with checking symptoms to disgust

Only washers demonstrate a neural response to washer-relevant disgust associated with emotion perception rather than attention to non-emotive visual detail, and this response is distinguished between washing and checking symptoms in OCD.

Obsessive-compulsive disorder associated with brain lesions

The results suggest that acquired and idiopathic OCDs may share a common pathophysiologic mechanism, and that structural damage to specific frontal-limbic-subcortical circuits plays an important role in the pathogenesis of acquired OCD.

Disgust sensitivity, trait anxiety and anxiety disorders symptoms in normal children.

A neuro-evolutionary approach to the anxiety disorders.

Disgust sensitivity in eating disorders: a preliminary investigation.

Although patients are not more sensitive than controls to the disgust-eliciting stimuli measured, disgust still has a positive relationship to eating disorder symptoms, and future studies will need to examine more precisely what this relationship might be.