The psychoactive ingredient of marijuana induces behavioural sensitization.

  title={The psychoactive ingredient of marijuana induces behavioural sensitization.},
  author={T Rubino and Daniela Vigan{\`o} and Paola Massi and Daniela Parolaro},
  journal={The European journal of neuroscience},
  volume={14 5},
Here we describe, for the first time, the occurrence of behavioural sensitization after chronic exposure to Delta9-tetrahydrocannabinol. Rats were treated twice a day, for five days, with increasing doses (5, 10, 20, 40, 40 mg/kg i.p.) of Delta9-tetrahydrocannabinol or its vehicle and after 20 days of withdrawal, animals were challenged with 5 mg/kg (i.p.) of the drug and their behaviour was assessed. Contrary to the motor inhibition induced in control rats, challenge with Delta9… CONTINUE READING

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