The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.


Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To define the specific role and molecular mechanism of MLKL action, we generated MLKL-deficient mice and solved the crystal structure of MLKL. Although MLKL-deficient mice were… (More)
DOI: 10.1016/j.immuni.2013.06.018


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