The pruritogenic effect of Anaphe venata extracts in rats: the role of cholinergic, GABAergic and opioid systems

  title={The pruritogenic effect of Anaphe venata extracts in rats: the role of cholinergic, GABAergic and opioid systems},
  author={K. Bamitale and M. Akanmu and O. Ukponmwan},
  journal={International Journal of Biological and Chemical Sciences},
This study sought to investigate the effect of the crude aqueous and phosphate buffer saline (PBS) extracts of Anaphe venata on body scratching behaviour in rat in a novel environment and also to determine the neural mechanism(s) involved. Aqueous and PBS extracts of Anaphe venata were prepared and their effects on body scratching behaviour were evaluated in rats. Animals were divided into four groups (n = 6-12 per group) and graded doses of extracts (100-400 mg/kg) were administered (dissolved… Expand

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