The pruritogenic effect of Anaphe venata extracts in rats: the role of cholinergic, GABAergic and opioid systems

@article{Bamitale2011ThePE,
  title={The pruritogenic effect of Anaphe venata extracts in rats: the role of cholinergic, GABAergic and opioid systems},
  author={K. Bamitale and M. Akanmu and O. Ukponmwan},
  journal={International Journal of Biological and Chemical Sciences},
  year={2011},
  volume={4}
}
This study sought to investigate the effect of the crude aqueous and phosphate buffer saline (PBS) extracts of Anaphe venata on body scratching behaviour in rat in a novel environment and also to determine the neural mechanism(s) involved. Aqueous and PBS extracts of Anaphe venata were prepared and their effects on body scratching behaviour were evaluated in rats. Animals were divided into four groups (n = 6-12 per group) and graded doses of extracts (100-400 mg/kg) were administered (dissolved… Expand

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References

SHOWING 1-10 OF 20 REFERENCES
Mechanisms of Chloroquine-Induced Body-Scratching Behavior in Rats Evidence of Involvement of Endogenous Opioid Peptides
TLDR
The novel results implicate opioidergic mechanisms, and confirm the efficacy of antihistamine and corticosteroids in chloroquine body scratching in rats, strongly suggests that the chlorquine-induced body-scratching behavior in the rat may be a useful experimental model for chloroquin-induced pruritus in humans. Expand
Sub-Acute Toxicity and Biochemical Effects of extracts of Anaphe venata larvae in mice
TLDR
The sub-acute toxicity study showed an increase in the behavioural components as tremor, jerking and stretching, after the administration of the extracts for 7 days, an indication of Ataxia syndrome. Expand
REM sleep deprivation decreases the grooming and shaking behaviour induced by enkephalinase inhibitor or opiate withdrawal
TLDR
Both the phosphoramidon-induced WDS in naive rats and naloxone-precipitated withdrawal WDS were decreased in REM sleep deprived rats compared with animals allowed normal sleep (control and stress groups). Expand
Frontiers in pruritus research: scratching the brain for more effective itch therapy.
This Review highlights selected frontiers in pruritus research and focuses on recently attained insights into the neurophysiological, neuroimmunological, and neuroendocrine mechanisms underlyingExpand
A double‐blind, placebo‐controlled study of the efficacy of thiamine hydrochloride in a seasonal ataxia in Nigerians
TLDR
The results of the first double-blind, placebo-controlled trial of the efficacy of thiamine hydrochloride in a seasonal ataxic syndrome of unknown etiology, endemic to the southwestern part of Nigeria represent the first advance in the elucidation of the etiology of this syndrome. Expand
Thiamine for Alzheimer's disease.
TLDR
There is no evidence that thiamine is a useful treatment for the symptoms of Alzheimer's disease, and the data are so poor and sparse that it is difficult to state almost anything of its effect in Alzheimer’s disease. Expand
Seasonal ataxic syndrome in a pregnant Nigerian woman
  • B. Adamolekun, B. Faleyimu, D. Selo-Ojeme
  • Medicine
  • International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 1993
TLDR
The rapid resolution of the neurological signs in this patient supports the hypothesis of acute thiamine deficiency as a cause of the ataxic syndrome, which usually occur in the rainy season in southwest Nigeria after an evening carbohydrate meal. Expand
Primer of Postoperative Pruritus for Anesthesiologists
TLDR
New discoveries in pathways and mechanisms of pruritus are highlighted and up-to-date knowledge about treatment of itching after surgery is summarized to address the effects of drugs on specific receptors and improve the treatment of postoperatively itching. Expand
Differences in Measures of Exploration and Fear in MHC-Congenic C57BL/6J and B6-H-2K Mice
MHC-congenic mice prefer to mate with mice of different MHC types and are able to discriminate between MHC-congenic mice by their urine odors, but nothing is known about behavioral differences amongExpand
A Toxicity Study of Thiamine Hydrochloride.
TLDR
Communications relative to membership in the Association and to all matters of business of the Association should be Communications relative to articles offered for publication addressed to the Administrative Secretary, AAAS, 1515 Mass. Expand
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