The proximal 350 bp of 5′-flanking sequence of the human α-subunit glycoprotein hormone gene functions in the pituitary gland, but not the placenta, in transgenic mice

To understand better the minimal DNA sequence requirements for regulated expression of the human α-subunit glycoprotein hormone gene (Hα), two lines of transgenic mice were constructed that contained a fusion gene (Hα-350CAT) consisting of only 350 bp of 5′-flanking sequence of Hα linked to the bacterial gene encoding chloramphenicol acetyltransferase (CAT… CONTINUE READING