The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat

@article{Fischer2002ThePM,
  title={The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat},
  author={A. Fischer and P. Rosenstiel and E. Fuchs and D. Goula and B. Cz{\'e}h},
  journal={Brain Research},
  year={2002},
  volume={947},
  pages={290-293}
}
  • A. Fischer, P. Rosenstiel, +2 authors B. Czéh
  • Published 2002
  • Medicine, Biology
  • Brain Research
  • Glucocorticoid receptor activation inhibits granule cell proliferation in the hippocampus, but little is known about the role of mineralocorticoid receptors in this process. Here we administered aldosterone to adrenalectomized (ADX) rats, and monitored neurogenesis by BrdU immunohistochemistry. ADX significantly increased the number of BrdU-positive cells and aldosterone replacement further augmented BrdU-positivity. Our results indicate that aldosterone, most probably acting through… CONTINUE READING
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