The protonmotive Q cycle: A general formulation

  title={The protonmotive Q cycle: A general formulation},
  author={Peter D. Mitchell},
  journal={FEBS Letters},
  • P. Mitchell
  • Published 15 November 1975
  • Psychology
  • FEBS Letters

Breaking the Q-cycle: finding new ways to study Qo through thermodynamic manipulations

The mystery behind the Qo site mechanism remains unsolved due to elusive kinetic intermediates duringQo site electron transfer that have not been detected spectroscopically, so it is necessary to look beyond traditional steady-state experimental approaches by changing cytochrome bc1 thermodynamics and promoting otherwise transient Qo sites redox states.

Fixing the Q cycle.

Quinone and non-quinone redox couples in Complex III

A better understanding of the engineering of Complex III is coming from a now moderately well defined thermodynamic description of the redox components as a function of pH, including the Qi/heme bH cluster.

Optimal efficiency of the Q-cycle mechanism around physiological temperatures from an open quantum systems approach

The present work suggests that the theory of quantum open systems can successfully push forward the theoretical understanding of complex biological systems working close to the quantum/classical boundary.

A structural perspective on mechanism and function of the cytochrome bc (1) complex.

The cytochrome bc (1) complex is a fundamental component of the energy conversion machinery of respiratory and photosynthetic electron transfer chains and as a major source of reactive oxygen species and its implication in pathophysiological conditions has recently gained interest.

Coupling between the Charge-Separating Devices of the Mitochondrion: Intra- or Extramembrane?

This past year has seen such a plethora of reviews and “mini-reviews” on the mechanism of oxidative phosphorylation (e.g., refs. 1–3) that it would be both tedious and arrogant of me to add to their

Evidence for a protonmotive Q cycle mechanism of electron transfer through the cytochrome b-c1 complex.

  • B. Trumpower
  • Biology, Chemistry
    Biochemical and biophysical research communications
  • 1976