The proto-oncogene Myc is essential for mammary stem cell function.

  title={The proto-oncogene Myc is essential for mammary stem cell function.},
  author={Mejdi Moumen and Aur{\'e}lie Chiche and Marie-Ange Deugnier and Val{\'e}rie Petit and Alberto Gandarillas and Marina A. Glukhova and Marisa M. Faraldo},
  journal={Stem cells},
  volume={30 6},
The mammary epithelium comprises two major cell lineages: basal and luminal. Basal cells (BCs) isolated from the mammary epithelium and transplanted into the mouse mammary fat pad cleared from the endogenous epithelium regenerate the mammary gland, strongly suggesting that the basal epithelial compartment harbors a long-lived cell population with multipotent stem cell potential. The luminal cell layer is devoid of the regenerative potential, but it contains cells with clonogenic capacity, the… CONTINUE READING
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