The proteostasis boundary in misfolding diseases of membrane traffic.

@article{Hutt2009ThePB,
  title={The proteostasis boundary in misfolding diseases of membrane traffic.},
  author={Darren M. Hutt and Evan T Powers and William Edward Balch},
  journal={FEBS letters},
  year={2009},
  volume={583 16},
  pages={
          2639-46
        }
}
Protein function is regulated by the proteostasis network (PN) [Balch, W.E., Morimoto, R.I., Dillin, A. and Kelly, J.W. (2008) Adapting proteostasis for disease intervention. Science 319, 916-919], an integrated biological system that generates and protects the protein fold. The composition of the PN is regulated by signaling pathways including the unfolded protein response (UPR), the heat-shock response (HSR), the ubiquitin proteasome system (UPS) and epigenetic programs. Mismanagement of… CONTINUE READING
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  • 2013
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  • Handbook of Experimental Pharmacology
  • 2018
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