The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

@article{Mller1993ThePT,
  title={The protein tyrosine kinase JAK1 complements defects in interferon-$\alpha$/$\beta$ and -$\gamma$ signal transduction},
  author={Mathias M{\"u}ller and J. Briscoe and C. Laxton and D. Guschin and A. Ziemiecki and O. Silvennoinen and A. Harpur and G. Barbieri and B. Witthuhn and C. Schindler and S. Pellegrini and A. Wilks and J. Ihle and G. Stark and lan M. Kerr},
  journal={Nature},
  year={1993},
  volume={366},
  pages={129-135}
}
We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-& alpha;/& beta; and -& gamma; signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-& alpha; pathway, and between JAK1 and JAK2 in the interferon-& gamma; pathway, may… Expand
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ*
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