The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.

@article{Lee2014ThePS,
  title={The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.},
  author={Clarissa C. Lee and Elizaveta Freinkman and David M. Sabatini and Hidde L. Ploegh},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 24},
  pages={17124-31}
}
Leucine-rich repeat-containing 8 (LRRC8) proteins have been identified as putative receptors involved in lymphocyte development and adipocyte differentiation. They remain poorly characterized, and no specific function has been assigned to them. There is no consensus on how this family of proteins might function because homology searches suggest that members of the LRRC8 family act not as plasma membrane receptors, but rather as channels that mediate cell-cell signaling. Here we provide… CONTINUE READING
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