The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.

@article{Croons2009ThePS,
  title={The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.},
  author={Valerie Croons and Wim Martinet and Arnold G. Herman and Jean-Pierre Timmermans and Guido R Y De Meyer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={329 3},
  pages={856-64}
}
Because macrophages play a major role in atherosclerotic plaque destabilization, selective removal of macrophages represents a promising approach to stabilize plaques. We showed recently that the protein synthesis inhibitor cycloheximide, in contrast to puromycin, selectively depleted macrophages in rabbit atherosclerotic plaques without affecting smooth muscle cells (SMCs). The mechanism of action of these two translation inhibitors is dissimilar and could account for the differential effects… CONTINUE READING

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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