The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.

@article{Ruvolo2014ThePP,
  title={The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.},
  author={Peter P Ruvolo and Vivian R Ruvolo and Rodrigo O. Jacamo and Jared K. Burks and Zhihong Zeng and Seshagiri R Duvvuri and Liran Zhou and Yihua Qiu and Kevin R. Coombes and Nianxiang Zhang and Suk Young Yoo and Rongqing Pan and Numsen Hail and Marina Y Konopleva and George A. Calin and Steven M. Kornblau and Michael Andreeff},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1843 9},
  pages={1969-77}
}
We recently discovered that the protein phosphatase 2A (PP2A) B55α subunit (PPP2R2A) is under-expressed in primary blast cells and is unfavorable for remission duration in AML patients. In this study, reverse phase protein analysis (RPPA) of 230 proteins in 511 AML patient samples revealed a strong correlation of B55α with a number of proteins including MYC, PKC α, and SRC. B55α suppression in OCI-AML3 cells by shRNA demonstrated that the B subunit is a PKCα phosphatase. B55α does not target… CONTINUE READING
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