The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.

Abstract

HL-60 cells are an attractive model for studies of human myeloid cell differentiation. Among the well-examined parameters correlated to differentiation of HL-60 cells are the expression and phosphorylation of the small heat shock protein Hsp27. Here we demonstrate that PMA treatment of HL-60 cells stimulates different MAP kinase cascades, leading to… (More)

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@article{Schultz1997ThePK, title={The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.}, author={Huguette Schultz and T Rogalla and Katherine Engel and Jang Choon Lee and Mathias Gaestel}, journal={Cell stress & chaperones}, year={1997}, volume={2 1}, pages={41-9} }