The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

@article{Yamaguchi2001ThePK,
  title={The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change},
  author={Hirohito Yamaguchi and Hong-Gang Wang},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={7779-7786}
}
The serine-threonine kinase Akt exerts its anti-apoptotic effects through several downstream targets, including the pro-apoptotic Bc1-2 family member Bad, Forkhead transcription factors, and the cyclic AMP response element-binding protein (CREB). In this report we demonstrate that Akt inhibits a conformational change in the pro-apoptotic Bax protein and its translocation to mitochondria, thus preventing the disruption of the mitochondrial inner membrane potential (ΔΨm), caspase-3 activation… CONTINUE READING
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