The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing.

Abstract

The splicing of mammalian mRNA precursors requires both protein phosphorylation and dephosphorylation, likely involving modification of members of the SR protein family of splicing factors. Several kinases have been identified that can phosphorylate SR proteins in vitro, and transfection assays have provided evidence that at least one of these, Clk/Sty, can… (More)

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@article{Prasad1999ThePK, title={The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing.}, author={Janaka Prasad and Karen Colwill and Trevor W. Pawson and J. L. Manley}, journal={Molecular and cellular biology}, year={1999}, volume={19 10}, pages={6991-7000} }