The protein kinase C signaling pathway regulates a molecular switch between transactivation and transrepression activity of the peroxisome proliferator-activated receptor alpha.

@article{Blanquart2004ThePK,
  title={The protein kinase C signaling pathway regulates a molecular switch between transactivation and transrepression activity of the peroxisome proliferator-activated receptor alpha.},
  author={Christophe Blanquart and Roxane M Mansouri and R{\'e}jane Paumelle and J. -C. Fruchart and Bart Staels and Corine Glineur},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 8},
  pages={
          1906-18
        }
}
Peroxisome proliferator-activated receptor (PPAR) alpha is a nuclear receptor implicated in several physiological processes such as lipid and lipoprotein metabolism, glucose homeostasis, and the inflammatory response. PPARalpha is activated by natural fatty acids and synthetic compounds like fibrates. PPARalpha activity has been shown to be modulated by its phosphorylation status. PPARalpha is phosphorylated by kinases such as the MAPKs and cAMP-activated protein kinase A. In this report, we… CONTINUE READING
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