The protein kinase C inhibitor, bisindolylmaleimide (I), inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.

@article{Park2005ThePK,
  title={The protein kinase C inhibitor, bisindolylmaleimide (I), inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.},
  author={Won Sun Park and Youn Kyoung Son and Eun Ah Ko and Jae-Hong Ko and Hyang Ae Lee and Kyoung Sun Park and Yung E. Earm},
  journal={Life sciences},
  year={2005},
  volume={77 5},
  pages={
          512-27
        }
}
We examined the effects of the protein kinase C (PKC) inhibitor, bisindolylmaleimide (BIM) (I), on voltage-dependent K+ (K(V)) channels in rabbit coronary arterial smooth muscle cells using whole-cell patch clamp technique. BIM (I) reversibly and dose-dependently inhibited the K(V) currents with an apparent Kd value of 0.27 microM. The inhibition of the K(V) current by BIM (I) was highly voltage-dependent between -30 and +10 mV (voltage range of channel activation), and the additive inhibition… CONTINUE READING
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