The protein kinase-C activation domain of the parathyroid hormone.

Abstract

The PTH activates both adenylate cyclase and a mechanism that increases membrane-associated protein kinase-C (PKC) activity. To define the hormone's PKC activation domain we have used a panel of PTH fragments and ROS 17/2 rat osteosarcoma cells as the target cells. PTH equally and maximally increased PKC activity in ROS 17/2 cell membranes at physiological… (More)

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Cite this paper

@article{Jouishomme1992ThePK, title={The protein kinase-C activation domain of the parathyroid hormone.}, author={H Jouishomme and James F. Whitfield and Balu R Chakravarthy and Jon P. Durkin and Ludovick Gagnon and Richard J. Isaacs and Susanne Maclean and Witold A. Neugebauer and Gordon E. Willick and Raymond H. Rixon}, journal={Endocrinology}, year={1992}, volume={130 1}, pages={53-60} }