The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

@article{Grille2003ThePK,
  title={The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.},
  author={Sylvia Julien Grille and Alfonso Bellacosa and John J. Upson and Andr{\'e}s J. P. Klein-Szanto and Frans van Roy and Whaseon Lee-Kwon and Mark Donowitz and Philip N Tsichlis and Lionel Larue},
  journal={Cancer research},
  year={2003},
  volume={63 9},
  pages={
          2172-8
        }
}
Epithelial-mesenchymal transition (EMT) is an important process during development and oncogenesis by which epithelial cells acquire fibroblast-like properties and show reduced intercellular adhesion and increased motility. Squamous cell carcinoma lines engineered to express constitutively active Akt underwent EMT, characterized by down-regulation of the epithelial markers desmoplakin, E-cadherin, and beta-catenin and up-regulation of the mesenchymal marker vimentin. The cells lost epithelial… CONTINUE READING

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