The protein kinase A-regulated cardiac CI− channel resembles the cystic fibrosis transmembrane conductance regulator

@article{Nagel1992ThePK,
  title={The protein kinase A-regulated cardiac CI− channel resembles the cystic fibrosis transmembrane conductance regulator},
  author={Georg Nagel and T E Hwang and Kent L. Nastiuk and Angus C. Nairn and David C. Gadsbyt},
  journal={Nature},
  year={1992},
  volume={360},
  pages={81-84}
}
STIMULATION of β-adrenoceptors in cardiac ventricular myocytes activates a strong chloride ion conductance1–5 as a result of phosphorylation by cyclic AMP-dependent protein kinase (PKA)2,4. This Cl− conductance, which is time- and voltage-independent1,5, counters2,5 the tendency of the simultaneously enhanced Ca2+ channel current to prolong the ventricular action potential. Using inside-out giant patches6 excised from guinea-pig myocytes, we show here that phosphorylation by the PKA catalytic… CONTINUE READING

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