The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase.

@article{Leemhuis2002ThePK,
  title={The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase.},
  author={Jost Leemhuis and St{\'e}phanie Boutillier and Gudula Schmidt and Dieter K. Meyer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={300 3},
  pages={1000-7}
}
The small GTPase RhoA can retract cell extensions by acting on two Rho kinases (ROCKs). Activated protein kinase A (PKA) inhibits RhoA and induces extensions. The isoquinoline H89 inhibits PKA and thus should prevent the inactivation of RhoA. In kinase assays, H89 has been recently found to inactivate a ROCK-II also. Because H89 may be able to exert opposite effects on cell extensions, we have studied the effects of H89 on neurite formation in the neuroblastoma-glioma line NG 108-15, which… CONTINUE READING
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