The protein interaction network of extracellular vesicles derived from human colorectal cancer cells.

@article{Choi2012ThePI,
  title={The protein interaction network of extracellular vesicles derived from human colorectal cancer cells.},
  author={Dong-Sic Choi and Jae-Seong Yang and Eun-jeong Choi and Su Chul Jang and Solip Park and Oh Youn Kim and Daehee Hwang and Kwang Pyo Kim and Yoon-Keun Kim and Sanguk Kim and Yong Song Gho},
  journal={Journal of proteome research},
  year={2012},
  volume={11 2},
  pages={
          1144-51
        }
}
Various mammalian cells including tumor cells secrete extracellular vesicles (EVs), otherwise known as exosomes and microvesicles. EVs are nanosized bilayered proteolipids and play multiple roles in intercellular communication. Although many vesicular proteins have been identified, their functional interrelationships and the mechanisms of EV biogenesis remain unknown. By interrogating proteomic data using systems approaches, we have created a protein interaction network of human colorectal… CONTINUE READING
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