The protein import motor of mitochondria

  title={The protein import motor of mitochondria},
  author={Walter Neupert and Michael Brunner},
  journal={Nature Reviews Molecular Cell Biology},
Proteins that are destined for the matrix of mitochondria are transported into this organelle by two translocases: the TOM complex, which transports proteins across the outer mitochondrial membrane; and the TIM23 complex, which gets them through the inner mitochondrial membrane. Two models have been proposed to explain how this protein-import machinery works — a targeted Brownian ratchet, in which random motion is translated into vectorial motion, or a 'power stroke', which is exerted by a… CONTINUE READING
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