The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation.

@article{Okamoto2002ThePI,
  title={The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation.},
  author={Koji Okamoto and Achim Brinker and Stefan A. Paschen and Ismail Moarefi and Manajit Hayer-Hartl and Walter Neupert and Michael Brunner},
  journal={The EMBO journal},
  year={2002},
  volume={21 14},
  pages={3659-71}
}
Unfolding and import of preproteins into mitochondria are facilitated by a molecular motor in which heat shock protein 70 (Hsp70) in the matrix plays an essential role. Here we present two different experimental approaches to analyze mechanisms underlying this function of Hsp70. First, preproteins containing stretches of glutamic acid (polyE) or glycine (polyG) repeats in front of folded domains were imported into mitochondria. This occurred although Hsp70 cannot pull on these stretches to… CONTINUE READING

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