The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity.

@article{ChooniedassKothari2010ThePE,
  title={The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity.},
  author={Shilpa Chooniedass-Kothari and Daniel Vincett and Yi Yan and Charlton Cooper and Mohammad Kariminia Hamedani and Yvonne Myal and Etienne Leygue},
  journal={FEBS letters},
  year={2010},
  volume={584 6},
  pages={1174-80}
}
The steroid receptor RNA activator gene (SRA1) encodes for a functional RNA (SRA) as well as a protein (SRAP). While several groups reported on SRA-RNA mechanism of action, SRAP exact function remains to be elucidated, mainly due to a lack of studies investigating the function of the protein independently of its RNA counterpart. Using two independent models to examine its specific functions, SRAP was found to enhance estrogen receptor alpha activity in a ligand and response-element dependent… CONTINUE READING

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