The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors

@article{Yanofsky1990ThePE,
  title={The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors},
  author={Martin F. Yanofsky and Hong Ma and John L. Bowman and Gary N. Drews and Kenneth A. Feldmann and Elliot M. Meyerowitz},
  journal={Nature},
  year={1990},
  volume={346},
  pages={35-39}
}
Mutations in the homeotic gene agamous of the plant Arabidopsis cause the transformation of the floral sex organs. Cloning and sequence analysis of agamous suggest that it encodes a protein with a high degree of sequence similarity to the DNA-binding region of transcription factors from yeast and humans and to the product of a homeotic gene from Antirrhinum. The agamous gene therefore probably encodes a transcription factor that regulates genes determining stamen and carpel development in wild… 
View on Nature
ncbi.nlm.nih.gov
1,411 Citations
Highly Influential Citations
84
Background Citations
568
Methods Citations
59
Results Citations
11

1,411 Citations

Citation Type

Citation Type

Activation of a floral homeotic gene in Arabidopsis.
TLDR
Analysis of a LEAFY-responsive enhancer in the homeotic gene AGAMOUS indicates that direct interaction of LEAFy with this enhancer is required for its activity in plants, and indicates that LEafY is a direct upstream regulator of floral homeotic genes.
Negative regulation of the Arabidopsis homeotic gene AGAMOUS by the APETALA2 product
The Tousled gene in A. thaliana encodes a protein kinase homolog that is required for leaf and flower development
A ubiquitously expressed MADS-box gene from Nicotiana tabacum
TLDR
The isolation of a cDNA from Nicotiana tabacum coding for a MADS-box protein which is expressed in both the floral and vegetative organs of the plant is described.
Activation of Floral Homeotic Genes in Arabidopsis
TLDR
The identity of floral organs in Arabidopsis thaliana is determined by homeotic genes, which are expressed in specific regions of the developing flower, and these are the floral meristem—identity genes LEAFY and APETALA1.
The homeotic gene APETALA3 of Arabidopsis thaliana encodes a MADS box and is expressed in petals and stamens
Redundant enhancers mediate transcriptional repression of AGAMOUS by APETALA2.
TLDR
Regulatory elements that mediate transcriptional repression of AGAMOUS by APETalA2 are identified and it is found that several redundant elements respond independently to loss of APETALA2 activity, independent of redundancy at the level of trans-regulators.
LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development.
  • J. Conner, Z. Liu
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
This work isolated the LEUNIG gene by using a map-based approach and showed that it encodes a glutamine-rich protein with seven WD repeats and is similar in motif structure to a class of functionally related transcriptional corepressors including Tup1 from yeast and Groucho from Drosophila.
Molecular basis of the cauliflower phenotype in Arabidopsis
Genetic studies demonstrate that two Arabidopsis genes, CAULIFLOWER and APETALA1, encode partially redundant activities involved in the formation of floral meristems, the first step in the…
Regulation of the arabidopsis floral homeotic gene APETALA1
...
...

References

SHOWING 1-10 OF 22 REFERENCES
Deficiens, a homeotic gene involved in the control of flower morphogenesis in Antirrhinum majus: the protein shows homology to transcription factors.
TLDR
A cDNA derived from the wild type defA+ gene has been cloned by differential screening of a subtracted ‘flower specific’ cDNA library by utilizing the somatic and germinal instability of defA‐1 mutants.
AP2 Gene Determines the Identity of Perianth Organs in Flowers of Arabidopsis thaliana.
TLDR
The analysis of the floral morphology and ontogeny of three mutants of Arabidopsis thaliana suggests that the AP2 gene is required early in floral development to direct primordia of the first and second whorls to develop as perianth rather than as reproductive organs.
Genes directing flower development in Arabidopsis.
TLDR
It seems that the wild-type alleles of these four genes allow cells to determine their place in the developing flower and thus to differentiate appropriately and is proposed that these genes may be involved in setting up or responding to concentric, overlapping fields within the flower primordium.
A Dwarf Mutant of Arabidopsis Generated by T-DNA Insertion Mutagenesis
TLDR
This report is the characterization of a dwarf mutant in which the phenotype is inherited as a single recessive nuclear mutation that cosegregates with both the kanamycin-resistance trait and the T-DNA insert.
Molecular cloning and characterization of GPA1, a G protein alpha subunit gene from Arabidopsis thaliana.
TLDR
A gene coding for a G protein alpha subunit from the flowering plant Arabidopsis thaliana, named GPA1, was isolated by using a DNA probe generated by polymerase chain reaction based on protein sequences from mammalian and yeast G proteinalpha subunits.
Isolation and characterization of novel mutants of Arabidopsis thaliana defective in flower development
TLDR
A number of mutants of Arabidopsis thaliana, a member of the mustard family, that have defects in flower development and morphogenesis are isolated, except for one mutant whose mutational loci still remain to be determined.
Cellular localization of soybean storage protein mRNA in transformed tobacco seeds.
TLDR
It is concluded that sequences required for embryo expression, temporal control, and cell specificity are linked to the beta-conglycinin gene, and that factors regulating beta-Conglycin in gene expression are compartmentalized within analogous soybean and tobacco seed regions.
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
Selection-expression plasmid vectors for use in genetic transformation of higher plants.
TLDR
Plasmid vectors containing both a selectable marker for plant transformation (kanamycin resistance) and a second, directly adjacent, divergent promoter for the transcription of inserted DNA fragments have been constructed, allowing simple insertional cloning of DNA fragments to be expressed in plants.
The molecular genetics of embryonic pattern formation in Drosophila
Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two…
...
...