The protein binding of diazepam and N-demethyldiazepam in patients with poor renal function.

@article{Kangas1976ThePB,
  title={The protein binding of diazepam and N-demethyldiazepam in patients with poor renal function.},
  author={Lauri Kangas and Jussi Kanto and Jennie Forsstr{\"o}m and E U Iisalo},
  journal={Clinical nephrology},
  year={1976},
  volume={5 3},
  pages={114-8}
}
The plasma protein binding of diazepam and of its main metabolite, N-demethyldiazepam, was measured in patients with renal disease and in healthy volunteers by ultracentrifugation. The total and non-protein bound concentrations of diazepam and N-demethyldiazepam, and the concentration of unconjugated oxazepam in the plasma were determined by gas… CONTINUE READING