The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis

@article{Borner1994ThePB,
  title={The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis},
  author={Christoph Borner and Isabelle Martinou and Chantal Mattmann and Martin Irmler and Elisabeth Sch{\"a}rer and J C Martinou and J. -M. Tschopp},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={126},
  pages={1059 - 1068}
}
Bcl-2 is a mitochondrial- and perinuclear-associated protein that prolongs the lifespan of a variety of cell types by interfering with programmed cell death (apoptosis). Bcl-2 seems to function in an antioxidant pathway, and it is believed that membrane attachment mediated by a COOH-terminal hydrophobic tail is required for its full activity. To identify critical regions in bcl-2 alpha for subcellular localization, activity, and/or interaction with other proteins, we created, by site-directed… CONTINUE READING

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