The protein arginine deiminases: Structure, function, inhibition, and disease.

@article{Bicker2013ThePA,
  title={The protein arginine deiminases: Structure, function, inhibition, and disease.},
  author={Kevin L Bicker and Paul R Thompson},
  journal={Biopolymers},
  year={2013},
  volume={99 2},
  pages={155-63}
}
The post-translational modification of histones has significant effects on overall chromatin function. One such modification is citrullination, which is catalyzed by the protein arginine deiminases (PADs), a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. Overexpression and/or increased PAD activity is observed in several diseases, including rheumatoid arthritis, Alzheimer… CONTINUE READING

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