The protein SdhA maintains the integrity of the Legionella-containing vacuole.

  title={The protein SdhA maintains the integrity of the Legionella-containing vacuole.},
  author={Elizabeth Creasey and Ralph R Isberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 9},
Legionella pneumophila directs the formation of a specialized vacuole within host cells, dependent on protein substrates of the Icm/Dot translocation system. Survival of the host cell is essential for intracellular replication of L. pneumophila. Strains lacking the translocated substrate SdhA are defective for intracellular replication and activate host cell death pathways in primary macrophages. To understand how SdhA promotes evasion of death pathways, we performed a mutant hunt to identify… CONTINUE READING
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