The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.

@article{Sorbara2013ThePA,
  title={The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.},
  author={Matthew T. Sorbara and Lisa K Ellison and Mahendrasingh Ramjeet and Leonardo H. Travassos and Nicola Louise Jones and Stephen E. Girardin and Dana J Philpott},
  journal={Immunity},
  year={2013},
  volume={39 5},
  pages={858-73}
}
The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-independent role for ATG16L1 in negatively regulating Nod-driven inflammatory responses. Knockdown of ATG16L1 expression, but not that of ATG5 or ATG9a, specifically enhanced Nod… CONTINUE READING

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Nod 1 and Nod 2 direct autophagy by recruiting ATG 16 L 1 to the plasma membrane at the site of bacterial entry

  • L. H. Travassos, L. A. Carneiro, +7 authors L. Le Bourhis
  • Nat . Immunol .
  • 2010
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