The protective role of montelukast against intestinal ischemia-reperfusion injury in rats

@inproceedings{Wu2015ThePR,
  title={The protective role of montelukast against intestinal ischemia-reperfusion injury in rats},
  author={Shenbao Wu and Xuxing Zhu and Zhonghai Jin and Xiuping Tong and Liqin Zhu and Xiaofei Hong and Xianfei Zhu and Pengfei Liu and Weidong Shen},
  booktitle={Scientific reports},
  year={2015}
}
Several drugs are effective in attenuating intestinal ischemia-reperfusion injury (IRI); however little is known about the effect of montelukast. Fifty rats were randomly assigned to 3 groups: model group (operation with clamping), sham group (operation without clamping), and study group (operation with clamping and 0.2, 2 and 20 mg/kg montelukast pretreatment). Intestinal ischemia-reperfusion was performed by occlusion (clamping) of the arteria mesenterica anterior for 45 min, followed by 24 h… CONTINUE READING

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