The protective role of host Toll-like receptor-4 in acute graft-versus-host disease.

@article{Imado2010ThePR,
  title={The protective role of host Toll-like receptor-4 in acute graft-versus-host disease.},
  author={Takehito Imado and Tsuyoshi Iwasaki and Sachie Kitano and Atsushi Satake and Takanori Kuroiwa and Sachi Tsunemi and Hajime Sano},
  journal={Transplantation},
  year={2010},
  volume={90 10},
  pages={1063-70}
}
BACKGROUND Mutations in Toll-like receptor (TLR)-4 have been associated with the hyporesponsiveness of macrophages to lipopolysaccharide, possibly reducing the risk of acute graft-versus-host disease (GVHD). However, TLR-4 mutations may also increase the risk of intestinal damage and microbial infection, thereby accelerating acute GVHD. METHODS In this study, we investigated the role of TLR-4 in triggering acute GVHD using C3H/HeJ mice with disrupted TLR-4 and C3H/HeN mice with intact TLR-4… CONTINUE READING
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