The protective mechanisms induced by a fish rhabdovirus DNA vaccine depend on temperature.

@article{Lorenzen2009ThePM,
  title={The protective mechanisms induced by a fish rhabdovirus DNA vaccine depend on temperature.},
  author={Ellen Lorenzen and Katja Einer-Jensen and Jesper Skou Rasmussen and Thomas Kjaer and Bertrand Collet and Christopher J Secombes and Niels Lorenzen},
  journal={Vaccine},
  year={2009},
  volume={27 29},
  pages={3870-80}
}
DNA vaccines encoding the viral glycoproteins of viral haemorrhagic septicaemia virus (VHSV) and infectious haematopoietic necrosis virus (IHNV) have proved highly efficient in rainbow trout (Oncorhynchus mykiss) under experimental conditions. Non-specific as well as specific immune mechanisms seem to be activated. Temperature is an important external parameter affecting the immune response in fish. The present study aimed at determining the effectiveness of a DNA vaccine against VHS at… CONTINUE READING
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