The protective effects of pomelo extract (Citrus grandis L. Osbeck) against fructose-mediated protein oxidation and glycation

  title={The protective effects of pomelo extract (Citrus grandis L. Osbeck) against fructose-mediated protein oxidation and glycation},
  author={Natarin Caengprasath and Sathaporn Ngamukote and Kittana M{\"a}kynen and Sirichai Adisakwattana},
  journal={EXCLI Journal},
  pages={491 - 502}
Chronic hyperglycemia induces non-enzymatic protein glycation, which plays an important role in the development of diabetic complications. [] Key Result Our results showed that the pomelo extract (0.25 - 2.00 mg/mL) significantly inhibited the overall formation of advanced glycation end products (AGEs) in a concentration-dependent manner. The pomelo extract markedly decreased the level of fructosamine, which is directly associated with reduction in formation of AGEs and N (ε)-(carboxymethyl)lysine (CML).

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