The protective effects of pomelo extract (Citrus grandis L. Osbeck) against fructose-mediated protein oxidation and glycation

@article{Caengprasath2013ThePE,
  title={The protective effects of pomelo extract (Citrus grandis L. Osbeck) against fructose-mediated protein oxidation and glycation},
  author={Natarin Caengprasath and Sathaporn Ngamukote and Kittana M{\"a}kynen and Sirichai Adisakwattana},
  journal={EXCLI Journal},
  year={2013},
  volume={12},
  pages={491 - 502}
}
Chronic hyperglycemia induces non-enzymatic protein glycation, which plays an important role in the development of diabetic complications. [] Key Result Our results showed that the pomelo extract (0.25 - 2.00 mg/mL) significantly inhibited the overall formation of advanced glycation end products (AGEs) in a concentration-dependent manner. The pomelo extract markedly decreased the level of fructosamine, which is directly associated with reduction in formation of AGEs and N (ε)-(carboxymethyl)lysine (CML).

Figures and Tables from this paper

Inhibitory effect of Clitoria ternatea flower petal extract on fructose-induced protein glycation and oxidation-dependent damages to albumin in vitro

The results showed that Clitoria ternatea extract has strong antiglycation and antioxidant properties and might have therapeutic potentials in the prevention of AGE-mediated diabetic complications.

Mesona Chinensis Benth extract prevents AGE formation and protein oxidation against fructose-induced protein glycation in vitro

The extract of MC inhibited the formation of fluorescence AGEs in fructose-glycated bovine serum albumin (BSA) during 4 weeks of study, suggesting this edible plant could be a natural rich source of antiglycation agent for preventing AGE-mediated diabetic complication.

Glucose-mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase.

The present article tries to justify the wide use of Ceratonia siliqua L. in Moroccan folk medicine, demonstrating that the methanolic extract of leaves from this species presents a promising source of new natural compounds inhibiting acetylcholinesterase and acting in vitro against glycation generated compounds.

Extract of Leaves of Moringa stenopetala Alleviates Glycation in In vitro Model

This study was conducted to characterize antiglycation activity of ethanol extract of Moringa stenopetala leaves in a bovine serum albumin (BSA)/fructose system. Antiglycation activity was determined

Inhibitory Effect of Bunium Persicum Hydroalcoholic Extract on Glucose-Induced Albumin Glycation, Oxidation, and Aggregation In Vitro

The results showed that BPE has anti-glycation and antioxidant properties and might have therapeutic potentials in the prevention of glycation-mediated diabetic complications.

Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes

In a diabetic rat model, the levels of blood glucose, serum malondialdehyde, cholesterol, triglycerides, and low‐density lipoproteins were effectively reduced by PE treatment, and the activates of liver function‐related enzymes including alkaline phosphatase (ALP), glutamate pyruvate transaminase (GPT), and glutamate oxaloacetate transamination in diabetic rat were improved by PE.

Protein glycation inhibitory activity and antioxidant capacity of clove extract

The results clearly demonstrated that a polyphenol enriched clove extract, owing to its antioxidant, was capable to inhibit the formation of AGEs and protein glycation.

Antioxidant, Antiglycation and Anti-Hyperlipidemic Effects of Trigonella foenum and Cinnamon in Type 2 Diabetic Rats

The findings illustrated that Cinnamon and Trigonella foenum extract improved hyperlipidemia and hyperglycemic and showed significant anti-diabetic effects in animal model by reducing blood glucose and inhibition of AGEs and fructosamine formation.

Evaluation of Antidiabetic, Antihyperlipidemic, and Antiglycation Effect of Moringa stenopetala (Baker f) Cufodontis leaves

Background: Moringa stenopetala has been used in traditional health systems to treat diabetes mellitus. One of the successful methods to prevent onset of diabetes is to control postprandial

References

SHOWING 1-10 OF 41 REFERENCES

Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation.

  • A. ArdestaniR. Yazdanparast
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2007

Evaluation of α-glucosidase, α-amylase and protein glycation inhibitory activities of edible plants

It was found that Pennywort maintained the high percentage inhibition among those of the extracts during the 4 weeks of experiment, and these edible plants may be used for controlling blood glucose level and prevention of the development of type 2 diabetes.

Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts.

  • Chi-Hao WuG. Yen
  • Chemistry, Medicine
    Journal of agricultural and food chemistry
  • 2005
The objective of this study was to investigate the inhibitory effect of naturally occurring flavonoids on individual stage of protein glycation in vitro using the model systems of

Inhibition of advanced glycation endproduct formation by foodstuffs.

The development and investigation of AGE inhibitors, especially the natural anti-AGE agents without adverse effects, may provide a therapeutic approach for delaying and preventing premature aging and diabetic complications.

Cinnamic Acid and Its Derivatives Inhibit Fructose-Mediated Protein Glycation

It is demonstrated that cinnamic acid and its derivatives significantly inhibited the formation of advanced glycation end products (AGEs) by approximately 11.96–63.36% at a concentration of 1 mM.

Inhibition of protein glycation by extracts of culinary herbs and spices.

In general, spice extracts inhibited glycation more than herb extracts, but inhibition was correlated with total phenolic content, and extracts of powdered ginger and bay leaf were less effective than expected, and black pepper was more effective.

The effect of flavonoid treatment on the glycation and antioxidant status in Type 1 diabetic patients.

The results suggest that the flavonoid-induced decrease in glycation is associated with an increase in the antioxidant component dependent on the levels and activities of thiol-containing proteins such as glutathione peroxidase.

Naturally occurring inhibitors against the formation of advanced glycation end-products.

The Maillard reaction, the formation process of AGEs and harmful effects of A GEs to human health are introduced and typical effective AGE inhibitors with different inhibition mechanisms are reviewed in this paper.