The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication.

@article{Ishikawa2013ThePE,
  title={The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication.},
  author={Hiroki Ishikawa and Naoki Awano and Toshie Fukui and Hiraku Sasaki and Shigeru Kyuwa},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={434 4},
  pages={791-6}
}
The purpose of this study was to evaluate the effects of bovine lactoferrin against norovirus infection using mouse norovirus (MNV) and Raw264.7 cell in vitro. When Raw264.7 cells were infected with MNV in the presence or absence of lactoferrin, the cytotoxic damage to the infected Raw264.7 cells significantly and dose-dependently decreased and completely inhibited in the presence of 15 or 20 μg/well of lactoferrin as compared with the absence of lactoferrin. Correspondingly, the MNV titers in… CONTINUE READING