The protective effects of allopurinol and superoxide dismutase on noise-induced cochlear damage.

@article{Seidman1993ThePE,
  title={The protective effects of allopurinol and superoxide dismutase on noise-induced cochlear damage.},
  author={Stephen B. Seidman and Bhagyalakshmi G. Shivapuja and Wayne S. Quirk},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  year={1993},
  volume={109 6},
  pages={
          1052-6
        }
}
Several studies have demonstrated that noise exposure may result in local vasoconstriction of cochlear vessels. The subsequent decrease in cochlear blood flow may lead to hypoxia and predispose to the formation of free oxygen radicals (FORs). If hypoxia occurs in response to noise exposure, then drugs that scavenge or block the formation of FORs should protect the cochlea from damage resulting from hypoxic or ischemic events as well as noise trauma. Rats were exposed to 60 hours of continuous… CONTINUE READING
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