The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury.

@article{Kerr2008ThePE,
  title={The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury.},
  author={Bradley J Kerr and Elizabeth I Girolami and Nader Ghasemlou and Suh Young Jeong and Samuel Paul David},
  journal={Glia},
  year={2008},
  volume={56 4},
  pages={436-48}
}
Secondary tissue damage that occurs within days after spinal cord injury contributes significantly to permanent paralysis, sensory loss, and other functional disabilities. The acute inflammatory response is thought to contribute largely to this secondary damage. We show here that 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), a metabolite of prostaglandin D2 (PGD2) that has anti-inflammatory actions, given daily for the first 2 weeks after spinal cord contusion injury in mice, results in… CONTINUE READING
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