The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats.

@article{Erdem2000ThePE,
  title={The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats.},
  author={Atilla Erdem and Nimet Unay G{\"u}ndogan and Alp Usub{\"u}t{\"u}n and Kam{\'e}r Kilinç and Saban Remzi Erdem and Aslihan Kara and Ali Ihsan Bozkurt},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2000},
  volume={15 8},
  pages={1175-82}
}
BACKGROUND Taurine, which is the major intracellular free beta-amino acid, is known to be an endogenous antioxidant and a membrane-stabilizing agent. In this study, we wished to know whether taurine altered the concentration of gentamicin in kidney tissue and could protect against gentamicin-induced acute proximal tubular injury. METHODS Wistar albino rats of both sexes were assigned to three groups, which all received one of the following daily intraperitoneal injections for 8 days: (i) 0.9… CONTINUE READING
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