The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats.

@article{Hagar2004ThePE,
  title={The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats.},
  author={Hanan H. Hagar},
  journal={Toxicology letters},
  year={2004},
  volume={151 2},
  pages={
          335-43
        }
}
Cyclosporine A (CsA) is the immunosuppressor which is most frequently used in transplant surgery and in the treatment of autoimmune diseases. Oxidative stress has been implicated as one of the possible mechanisms of CsA-induced hepatotoxicity. The present investigation examined the ability of taurine as an antioxidant to protect against CsA-induced oxidative stress and hepatotoxicity. CsA hepatotoxicity was induced by subcutaneous injection of CsA at a dose of 20mg/kg body weight daily for 21… CONTINUE READING

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