The protective effect of supplemental calcium on colonic permeability depends on a calcium phosphate-induced increase in luminal buffering capacity

@article{Schepens2011ThePE,
  title={The protective effect of supplemental calcium on colonic permeability depends on a calcium phosphate-induced increase in luminal buffering capacity},
  author={Marloes A. A. Schepens and Sandra J M ten Bruggencate and Arjan J. Schonewille and Robert Jan Brummer and Roelof van der Meer and Ingeborg M. J. Bovee-Oudenhoven},
  journal={British Journal of Nutrition},
  year={2011},
  volume={107},
  pages={950 - 956}
}
An increased intestinal permeability is associated with several diseases. Previously, we have shown that dietary Ca decreases colonic permeability in rats. This might be explained by a calcium-phosphate-induced increase in luminal buffering capacity, which protects against an acidic pH due to microbial fermentation. Therefore, we investigated whether dietary phosphate is a co-player in the effect of Ca on permeability. Rats were fed a humanised low-Ca diet, or a similar diet supplemented with… Expand
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